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  1. Research Article

    Autocatalytic sets in E. coli metabolism

    A central unsolved problem in early evolution concerns self-organization towards higher complexity in chemical reaction networks. In theory, autocatalytic sets have useful properties to help model such transit...

    Filipa L Sousa, Wim Hordijk, Mike Steel and William F Martin

    Journal of Systems Chemistry 2015 6:4

    Published on: 1 April 2015

  2. Research article

    Cyclic growth of hierarchical structures in the aluminum-silicate system

    Biological structures grow spontaneously from a seed, using materials supplied by the environment. These structures are hierarchical, with the ‘building blocks’ on each level constructed from those on the lowe...

    Agnieszka Dyonizy, Vitaliy Kaminker, Joanna Wieckowska, Tomasz Krzywicki, Jim Pantaleone, Piotr Nowak and Jerzy Maselko

    Journal of Systems Chemistry 2015 6:3

    Published on: 6 March 2015

  3. Commentary

    On the divide between animate and inanimate

    Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, fo...

    Arto Annila and Erkki Kolehmainen

    Journal of Systems Chemistry 2015 6:2

    Published on: 19 February 2015


    Autocatalytic sets and boundaries

    Autopoietic systems, chemotons, and autogens are models that aim to explain (the emergence of) life as a functionally closed and self-sustaining system. An essential element in these models is the notion of a ...

    Wim Hordijk and Mike Steel

    Journal of Systems Chemistry 2015 6:1

    Published on: 12 February 2015

  5. Research article

    Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization

    Fatty acid vesicles are an important part of protocell models currently studied. As protocells can be considered as pre-biological precursors of cells, the models try to contribute to a better understanding of...

    Kishore Lingam Gangadhara, Puneet Srivastava, Jef Rozenski, Henri-Philippe Mattelaer, Volker Leen, Wim Dehaen, Johan Hofkens, Eveline Lescrinier and Piet Herdewijn

    Journal of Systems Chemistry 2014 5:5

    Published on: 9 December 2014

  6. Research article

    Serial transfer can aid the evolution of autocatalytic sets

    The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life s...

    Wim Hordijk, Nilesh Vaidya and Niles Lehman

    Journal of Systems Chemistry 2014 5:4

    Published on: 26 April 2014

  7. Research article

    Autocatalytic sets in a partitioned biochemical network

    In previous work, RAF theory has been developed as a tool for making theoretical progress on the origin of life question, providing insight into the structure and occurrence of self-sustaining and collectively...

    Joshua I Smith, Mike Steel and Wim Hordijk

    Journal of Systems Chemistry 2014 5:2

    Published on: 3 March 2014

  8. Research article

    Inferring chemical reaction patterns using rule composition in graph grammars

    Modeling molecules as undirected graphs and chemical reactions as graph rewriting operations is a natural and convenient approach to modeling chemistry. Graph grammar rules are most naturally employed to model...

    Jakob L Andersen, Christoph Flamm, Daniel Merkle and Peter F Stadler

    Journal of Systems Chemistry 2013 4:4

    Published on: 6 June 2013

  9. Research article

    Pathway control in the self-construction of complex precipitation forms in a Cu(II)-oxalate system

    Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded informatio...

    Agota Toth, Dezso Horvath, Akos Kukovecz, Maciej Maselko, Anne Baker, Shareen Ali and Jerzy Maselko

    Journal of Systems Chemistry 2012 3:4

    Published on: 2 August 2012

  10. Perspectives

    The eightfold path to non-enzymatic RNA replication

    The first RNA World models were based on the concept of an RNA replicase - a ribozyme that was a good enough RNA polymerase that it could catalyze its own replication. Although several RNA polymerase ribozymes...

    Jack W Szostak

    Journal of Systems Chemistry 2012 3:2

    Published on: 3 February 2012

  11. Preliminary communication

    Exploding vesicles

    While studying fatty acid vesicles as model primitive cell membranes, we encountered a dramatic phenomenon in which light triggers the sudden rupture of micron-scale dye-containing vesicles, resulting in rapid...

    Ting F Zhu and Jack W Szostak

    Journal of Systems Chemistry 2011 2:4

    Published on: 1 December 2011

  12. Research article

    A stochastic model of the emergence of autocatalytic cycles

    Autocatalytic cycles are rather common in biological systems and they might have played a major role in the transition from non-living to living systems. Several theoretical models have been proposed to addres...

    Alessandro Filisetti, Alex Graudenzi, Roberto Serra, Marco Villani, Davide De Lucrezia, Rudolf M Füchslin, Stuart A Kauffman, Norman Packard and Irene Poli

    Journal of Systems Chemistry 2011 2:2

    Published on: 22 June 2011

  13. Research article

    Dynamic combinatorial chemistry at the phospholipid bilayer interface

    Molecular recognition at the environment provided by the phospholipid bilayer interface plays an important role in biology and is subject of intense investigation. Dynamic combinatorial chemistry is a powerful...

    Friederike M Mansfeld, Ho Yu Au-Yeung, Jeremy KM Sanders and Sijbren Otto

    Journal of Systems Chemistry 2010 1:12

    Published on: 8 September 2010

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