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Table 1 Rate constants defined in Figure 1 for thioester exchange and hydrolysis at different temperatures and pHs.

From: Dynamic combinatorial chemistry at the phospholipid bilayer interface

starting material pH T [°C] k 1 [M-1s-1] k -1 [M-1s-1] k h1 [s-1] k 1 /k -1 K [a]
1a 7.0 40 0.868 × 10-2 ± 1.8 × 10-4 3.51 × 10-2 ± 1.3 × 10-3 5 × 10-5 ± 2 × 10-5 0.25 0.29
  8.0 40 7.58 × 10-2 ± 6.8 × 10-3 18.5 × 10-2 ± 2.3 × 10-2 1.1 × 10-4 ± 1 × 10-5 0.41 0.43
   30 2.93 × 10-2 ± 3 × 10-4 6.42 × 10-2 ± 1.1 × 10-3 6 × 10-5 ± 1 × 10-5 0.46 0.46
   20 1.22 × 10-2 ± 1 × 10-4 2.92 × 10-2 ± 4 × 10-4 2 × 10-5 1 × 10-5 0.42 0.44
1b 7.0 40 1.08 × 10-2 ± 2 × 10-4 1.00 × 10-2 ± 8 × 10-4 1.64 × 10-3 ± 3 × 10-5 1.08 1.10
  8.0 40 8.13 × 10-2 ± 1.4 × 10-3 6.12 × 10-2 ± 2.1 × 10-3 2.29 × 10-3 ± 3 × 10-5 1.33 1.28
   30 4.09 × 10-2 ± 1.2 × 10-3 4.01 × 10-2 ± 2.1 × 10-3 8.0 × 10-4 ± 4 × 10-5 1.02 1.08
   20 1.54 × 10-2 ± 2 × 10-4 1.69 × 10-2 ± 6 × 10-4 3.2 × 10-4 ± 2 × 10-5 0.91 0.92
  1. a Determined from the concentrations of thiol and thioesters observed in the equilibrated libraries.