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Table 1 Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N,N'-dimethylpiperazine 3.

From: Spontaneous absolute asymmetric synthesis promoted by achiral amines in conjunction with asymmetric autocatalysis

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Pyrimidyl alkanol2

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Pyrimidyl alkanol2

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Pyrimidyl alkanol2

 

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Config.

 

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1

19

R

26

3

R

52

36

S

2

18

S

27

7

S

53

23

S

3

8

R

28

4

S

54

32

R

4

10

S

29

14

R

55

32

S

5

11

R

30

6

S

56

4

S

6

8

S

31

6

R

57

6

R

7

5

S

32

4

S

58

12

S

8

9

R

33

4

R

59

15

S

9

6

S

34

3

S

60

5

S

10

4

S

35

15

S

61

42

R

11

4

S

36

20

S

62

52

R

12

57

R

37

18

R

63

2

S

13

2

R

38

9

R

64

43

R

14

37

S

39

37

S

65

35

R

15

23

R

40

27

S

66

3

S

16

4

S

41

28

R

67

2

R

17

6

R

42

3

R

68

4

S

18

4

S

43

9

S

69

4

S

19

7

S

44

32

S

70

42

R

20

47

R

45

29

R

71

32

R

21

29

R

46

11

S

72

18

R

22

25

R

47

16

R

73

6

S

23

10

S

48

52

R

74

9

R

24

12

S

49

9

R

75

19

R

25

31

R

50

4

S

   

26

12

S

51

19

R

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