Table 3 Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N-methylmorpholine 5.
Run | Pyrimidyl alkanol 2 | Run | Pyrimidyl alkanol 2 | Run | Pyrimidyl alkanol 2 | |||
|---|---|---|---|---|---|---|---|---|
| Â | ee | Config. | Â | ee | Config. | Â | ee | Config. |
1 | 34 | S | 8 | 15 | R | 15 | 6 | S |
2 | 37 | R | 9 | 33 | S | 16 | 9 | R |
3 | 52 | S | 10 | 7 | R | 17 | 29 | R |
4 | 33 | S | 11 | 10 | S | 18 | 12 | S |
5 | 20 | R | 12 | 6 | S | 19 | 12 | R |
6 | 16 | R | 13 | 7 | R | 20 | 27 | S |
7 | 33 | S | 14 | 7 | S | Â | Â | Â |