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Table 3 Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N-methylmorpholine 5.

From: Spontaneous absolute asymmetric synthesis promoted by achiral amines in conjunction with asymmetric autocatalysis

Run Pyrimidyl alkanol 2 Run Pyrimidyl alkanol 2 Run Pyrimidyl alkanol 2
  ee Config.   ee Config.   ee Config.
1 34 S 8 15 R 15 6 S
2 37 R 9 33 S 16 9 R
3 52 S 10 7 R 17 29 R
4 33 S 11 10 S 18 12 S
5 20 R 12 6 S 19 12 R
6 16 R 13 7 R 20 27 S
7 33 S 14 7 S