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Table 4 Assigned mean ± standard deviation values of Ka for the synthetic hosts used in the simulation and summary of binding constants for various interactions observed experimentally in biological systems as tabulated by Houk[50].

From: Deconvolution of a multi-component interaction network using systems chemistry

Host type

Guest type

Mean (log Ka)

β-cyclodextrin

Organic molecule

4 ± 2

CB[6]

Organic molecule

6 ± 2

CB[7]

Organic molecule

8 ± 3

CB[8]

Organic molecule

8 ± 3

Catalytic antibody

Transition state

6.6 ± 2.0[50]

Receptor

Drug

7.3 ± 1.5[50]

Antibody

Antigen

8.1 ± 2.0[50]

Enzyme

Inhibitor

8.6 ± 2.1[50]