Skip to main content

Table 4 Assigned mean ± standard deviation values of Ka for the synthetic hosts used in the simulation and summary of binding constants for various interactions observed experimentally in biological systems as tabulated by Houk[50].

From: Deconvolution of a multi-component interaction network using systems chemistry

Host type Guest type Mean (log Ka)
β-cyclodextrin Organic molecule 4 ± 2
CB[6] Organic molecule 6 ± 2
CB[7] Organic molecule 8 ± 3
CB[8] Organic molecule 8 ± 3
Catalytic antibody Transition state 6.6 ± 2.0[50]
Receptor Drug 7.3 ± 1.5[50]
Antibody Antigen 8.1 ± 2.0[50]
Enzyme Inhibitor 8.6 ± 2.1[50]