Figure 1

Defining amino acid coverage: examples of range and evenness for hypothetical amino acid sets. Amino acids are shown as dots on a linear descriptor (e.g. “LogP”). The set defined in (a) displays high range, but poor evenness. In (b), the set is highly even, but over a small range. The set in (c) is optimized for both range and evenness. Adapted from figure in Philip and Freeland [5].