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Table 6 Functional categories of the reactions affecting RAF size by more than 100 (“decr”)

From: Autocatalytic sets in E. coli metabolism

ID Functional annotation Reaction Decr
889 Murein Recycling LalaDgluMdap + h 2o → 26dap-M + LalaDglu 1389
200 Murein Recycling LalaDglu → LalaLglu 1386
892 Murein Recycling LalaLglu + h 2o → ala-L + glu-L 1384
713 Glutamate Metabolism atp + glu-L + nh 4 → adp + pi + h + gln-L 1371
421 Cofactor and Prosthetic Group Biosynthesis ru5p-D → db4p + h + for 1360
501 Cofactor and Prosthetic Group Biosynthesis g3p + h + pyr → co 2 + dxyl5p 1354
274 Cofactor and Prosthetic Group Biosynthesis 5apru + h + nadph → 5aprbu + nadp 1353
303 Alanine and Aspartate Metabolism glu-L + oaa → akg + asp-L 1353
464 Cofactor and Prosthetic Group Biosynthesis 25drapp + h + h 2o → 5apru + nh 4 1353
503 Cofactor and Prosthetic Group Biosynthesis e4p + h 2o + nad → 4per + h + h + nadh 1353
629 Cofactor and Prosthetic Group Biosynthesis atp + fmn + h → fad + ppi 1353
697 Nucleotide Salvage Pathway atp + gmp → adp + gdp 1353
749 Purine and Pyrimidine Biosynthesis atp + gln-L + h 2o + xmp → amp + ppi + h + h + gmp + glu-L 1353
769 Cofactor and Prosthetic Group Biosynthesis gtp + h 2o + h 2o + h 2o → 25drapp + ppi + h + h + for 1353
1039 Cofactor and Prosthetic Group Biosynthesis atp + nad → adp + nadp + h 1353
1045 Cofactor and Prosthetic Group Biosynthesis atp + dnad + nh 4 → amp + ppi + nad + h 1353
1086 Nucleotide Salvage Pathway atp + h + nicrnt → dnad + ppi 1353
1089 Cofactor and Prosthetic Group Biosynthesis h + h + prpp + quln → co 2 + ppi + nicrnt 1353
1141 Cofactor and Prosthetic Group Biosynthesis glu-L + ohpb → akg + phthr 1353
1183 Cofactor and Prosthetic Group Biosynthesis dxyl5p + nad + phthr → co 2 + pi + pdx5p + nadh + h 2o + h 2o + h 1353
1185 Cofactor and Prosthetic Group Biosynthesis 4per + nad → h + nadh + ohpb 1353
1225 Cofactor and Prosthetic Group Biosynthesis 5aprbu + h 2o → 4r5au + pi 1353
1326 Cofactor and Prosthetic Group Biosynthesis dhap + iasp → h 2o + quln + pi + h 2o 1353
1330 Cofactor and Prosthetic Group Biosynthesis atp + ribflv → adp + h + fmn 1353
1331 Cofactor and Prosthetic Group Biosynthesis 4r5au + db4p → dmlz + pi + h 2o + h 2o 1353
1332 Cofactor and Prosthetic Group Biosynthesis dmlz + dmlz → 4r5au + ribflv 1353
462 Purine and Pyrimidine Biosynthesis cbasp + h → dhor-S + h 2o 752
460 Purine and Pyrimidine Biosynthesis dhor-S + fum → orot + succ 750
1160 Purine and Pyrimidine Biosynthesis orot + prpp → orot5p + ppi 749
1148 Purine and Pyrimidine Biosynthesis h + orot5p → co 2 + ump 747
473 Tyrosine, Tryptophan, and Phenylalanine Metabolism 2dda7p → 3dhq + pi 726
768 Cofactor and Prosthetic Group Biosynthesis gtp + h 2o → ahdt + h + for 724
474 Tyrosine, Tryptophan, and Phenylalanine Metabolism 3dhq → 3dhsk + h 2o 723
1404 Tyrosine, Tryptophan, and Phenylalanine Metabolism 3dhsk + h + nadph → nadp + skm 722
1406 Tyrosine, Tryptophan, and Phenylalanine Metabolism atp + skm → adp + skm5p + h 720
1274 Tyrosine, Tryptophan, and Phenylalanine Metabolism pep + skm5p → 3psme + pi 719
350 Tyrosine, Tryptophan, and Phenylalanine Metabolism 3psme → chor + pi 717
1512 Nucleotide Salvage Pathway atp + ump → adp + udp 709
484 Cofactor and Prosthetic Group Biosynthesis ahdt + h 2o → dhpmp + ppi + h 693
483 Cofactor and Prosthetic Group Biosynthesis dhpmp + h 2o → dhnpt + pi 692
454 Cofactor and Prosthetic Group Biosynthesis dhnpt → 6hmhpt + gcald 687
1559 Cofactor and Prosthetic Group Biosynthesis chor + gln-L → 4adcho + glu-L 686
150 Cofactor and Prosthetic Group Biosynthesis 4adcho → 4abz + pyr + h 685
824 Cofactor and Prosthetic Group Biosynthesis 6hmhpt + atp → 6hmhptpp + h + amp 685
465 Cofactor and Prosthetic Group Biosynthesis 4abz + 6hmhptpp → dhpt + ppi 684
449 Cofactor and Prosthetic Group Biosynthesis atp + dhpt + glu-L → adp + pi + h + dhf 683
381 Purine and Pyrimidine Biosynthesis atp + gln-L + h 2o + utp → adp + pi + h + h + glu-L + ctp 679
447 Cofactor and Prosthetic Group Biosynthesis dhf + h + nadph → nadp + thf 674
114 Valine, Leucine, and Isoleucine Metabolism h + pyr + pyr → alac-S + co 2 639
875 Valine, Leucine, and Isoleucine Metabolism alac-S + h + nadph → 23dhmb + nadp 638
436 Valine, Leucine, and Isoleucine Metabolism 23dhmb → 3mob + h 2o 636
1017 Cofactor and Prosthetic Group Biosynthesis 3mob + h 2o + mlthf → 2dhp + thf 630
292 Cofactor and Prosthetic Group Biosynthesis asp-L + h → ala-B + co 2 629
487 Cofactor and Prosthetic Group Biosynthesis 2dhp + h + nadph → nadp + pant-R 629
1169 Cofactor and Prosthetic Group Biosynthesis ala-B + atp + pant-R → amp + ppi + pnto-R + h 628
1228 Cofactor and Prosthetic Group Biosynthesis atp + pnto-R → 4ppan + h + adp 627
1253 Cofactor and Prosthetic Group Biosynthesis 4ppan + ctp + cys-L → 4ppcys + ppi + h + cmp 626
1241 Cofactor and Prosthetic Group Biosynthesis 4ppcys + h → co 2 + pan4p 625
1295 Cofactor and Prosthetic Group Biosynthesis atp + h + pan4p → dpcoa + ppi 621
486 Cofactor and Prosthetic Group Biosynthesis atp + dpcoa → adp + h + coa 619
295 Threonine and Lysine Metabolism asp-L + atp → 4pasp + adp 197
286 Threonine and Lysine Metabolism 4pasp + h + nadph → aspsa + nadp + pi 195
831 Threonine and Lysine Metabolism aspsa + h + nadph → hom-L + nadp 187
800 Unassigned co 2 + h 2o → h + hco 3 174
833 Methionine Metabolism hom-L + succoa → coa + suchms 172
1407 Methionine Metabolism cys-L + suchms → cyst-L + succ + h 171
388 Methionine Metabolism cyst-L + h 2o → hcys-L + pyr + nh 4 170
983 Methionine Metabolism atp + h 2o + met-L → amet + ppi + pi 160
105 Membrane Lipid Metabolism accoa + atp + hco 3 → adp + pi + malcoa + h 117
971 Membrane Lipid Metabolism ACP + malcoa → coa + malACP 115
500 Cofactor and Prosthetic Group Biosynthesis dxyl5p + h + nadph → 2me4p + nadp 110
982 Cofactor and Prosthetic Group Biosynthesis 2me4p + ctp + h → 4c2me + ppi 109
343 Cofactor and Prosthetic Group Biosynthesis 4c2me + atp → 2p4c2me + h + adp 108
981 Cofactor and Prosthetic Group Biosynthesis 2p4c2me → 2mecdp + cmp 107
980 Cofactor and Prosthetic Group Biosynthesis 2mecdp + flxr + flxr + h → flxso + h 2o + h2mb4p + flxso 106
478 Cofactor and Prosthetic Group Biosynthesis dmpp + ipdp → grdp + ppi 101
  1. Chemical species are symbolic represented.