Table 2 Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N,N'-diethylpiperazine 4.
Run | Pyrimidyl alkanol 2 | Run | Pyrimidyl alkanol 2 | Run | Pyrimidyl alkanol 2 | |||
|---|---|---|---|---|---|---|---|---|
ee | Config. | ee | Config. | ee | Config. | |||
1 | 50 | S | 8 | 53 | S | 15 | 36 | S |
2 | 57 | R | 9 | 39 | R | 16 | 24 | S |
3 | 47 | R | 10 | 40 | R | 17 | 22 | R |
4 | 55 | S | 11 | 37 | S | 18 | 5 | S |
5 | 14 | R | 12 | 20 | S | 19 | 35 | R |
6 | 27 | R | 13 | 47 | R | 20 | 11 | S |
7 | 10 | R | 14 | 47 | R | |||