Skip to main content

Table 2 Asymmetric synthesis of pyrimidyl alkanol 2 without adding chiral substances by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 in the presence of N,N'-diethylpiperazine 4.

From: Spontaneous absolute asymmetric synthesis promoted by achiral amines in conjunction with asymmetric autocatalysis

Run Pyrimidyl alkanol 2 Run Pyrimidyl alkanol 2 Run Pyrimidyl alkanol 2
  ee Config.   ee Config.   ee Config.
1 50 S 8 53 S 15 36 S
2 57 R 9 39 R 16 24 S
3 47 R 10 40 R 17 22 R
4 55 S 11 37 S 18 5 S
5 14 R 12 20 S 19 35 R
6 27 R 13 47 R 20 11 S
7 10 R 14 47 R