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  1. Content type: Research Article

    A central unsolved problem in early evolution concerns self-organization towards higher complexity in chemical reaction networks. In theory, autocatalytic sets have useful properties to help model such transit...

    Authors: Filipa L Sousa, Wim Hordijk, Mike Steel and William F Martin

    Citation: Journal of Systems Chemistry 2015 6:4

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  2. Content type: Research article

    Biological structures grow spontaneously from a seed, using materials supplied by the environment. These structures are hierarchical, with the ‘building blocks’ on each level constructed from those on the lowe...

    Authors: Agnieszka Dyonizy, Vitaliy Kaminker, Joanna Wieckowska, Tomasz Krzywicki, Jim Pantaleone, Piotr Nowak and Jerzy Maselko

    Citation: Journal of Systems Chemistry 2015 6:3

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  3. Content type: Commentary

    Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, fo...

    Authors: Arto Annila and Erkki Kolehmainen

    Citation: Journal of Systems Chemistry 2015 6:2

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  4. Content type: PERSPECTIVES

    Autopoietic systems, chemotons, and autogens are models that aim to explain (the emergence of) life as a functionally closed and self-sustaining system. An essential element in these models is the notion of a ...

    Authors: Wim Hordijk and Mike Steel

    Citation: Journal of Systems Chemistry 2015 6:1

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  5. Content type: Research article

    Fatty acid vesicles are an important part of protocell models currently studied. As protocells can be considered as pre-biological precursors of cells, the models try to contribute to a better understanding of...

    Authors: Kishore Lingam Gangadhara, Puneet Srivastava, Jef Rozenski, Henri-Philippe Mattelaer, Volker Leen, Wim Dehaen, Johan Hofkens, Eveline Lescrinier and Piet Herdewijn

    Citation: Journal of Systems Chemistry 2014 5:5

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  6. Content type: Research article

    The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. For this concept to have significance in a realistic origins-of-life s...

    Authors: Wim Hordijk, Nilesh Vaidya and Niles Lehman

    Citation: Journal of Systems Chemistry 2014 5:4

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  7. Content type: Research article

    In previous work, RAF theory has been developed as a tool for making theoretical progress on the origin of life question, providing insight into the structure and occurrence of self-sustaining and collectively...

    Authors: Joshua I Smith, Mike Steel and Wim Hordijk

    Citation: Journal of Systems Chemistry 2014 5:2

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  8. Content type: Research article

    The assessment of molecular similarity is a key step in the drug discovery process that has thus far relied almost exclusively on computational approaches. We now report an experimental method for similarity a...

    Authors: Vittorio Saggiomo, Yana R Hristova, R Frederick Ludlow and Sijbren Otto

    Citation: Journal of Systems Chemistry 2013 4:2

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  9. Content type: Research article

    Many biological systems contain complex precipitation patterns. These structures are considered to be the result of finely tuned and genetically encoded developmental pathways. The amount of encoded informatio...

    Authors: Agota Toth, Dezso Horvath, Akos Kukovecz, Maciej Maselko, Anne Baker, Shareen Ali and Jerzy Maselko

    Citation: Journal of Systems Chemistry 2012 3:4

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  10. Content type: Perspectives

    The first RNA World models were based on the concept of an RNA replicase - a ribozyme that was a good enough RNA polymerase that it could catalyze its own replication. Although several RNA polymerase ribozymes...

    Authors: Jack W Szostak

    Citation: Journal of Systems Chemistry 2012 3:2

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  11. Content type: Research article

    A classical problem in metabolic design is to maximize the production of a desired compound in a given chemical reaction network by appropriately directing the mass flow through the network. Computationally, t...

    Authors: Jakob L Andersen, Christoph Flamm, Daniel Merkle and Peter F Stadler

    Citation: Journal of Systems Chemistry 2012 3:1

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  12. Content type: Preliminary communication

    While studying fatty acid vesicles as model primitive cell membranes, we encountered a dramatic phenomenon in which light triggers the sudden rupture of micron-scale dye-containing vesicles, resulting in rapid...

    Authors: Ting F Zhu and Jack W Szostak

    Citation: Journal of Systems Chemistry 2011 2:4

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  13. Content type: Research article

    Autocatalytic cycles are rather common in biological systems and they might have played a major role in the transition from non-living to living systems. Several theoretical models have been proposed to addres...

    Authors: Alessandro Filisetti, Alex Graudenzi, Roberto Serra, Marco Villani, Davide De Lucrezia, Rudolf M Füchslin, Stuart A Kauffman, Norman Packard and Irene Poli

    Citation: Journal of Systems Chemistry 2011 2:2

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  14. Content type: Preliminary communication

    The programmability and replicability of RNA and DNA have respectively enabled the design and selection of a number of allosteric ribozymes and deoxyribozymes. These catalysts have been adapted to function as ...

    Authors: Grace Eckhoff, Vlad Codrea, Andrew D Ellington and Xi Chen

    Citation: Journal of Systems Chemistry 2010 1:13

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  15. Content type: Research article

    Molecular recognition at the environment provided by the phospholipid bilayer interface plays an important role in biology and is subject of intense investigation. Dynamic combinatorial chemistry is a powerful...

    Authors: Friederike M Mansfeld, Ho Yu Au-Yeung, Jeremy KM Sanders and Sijbren Otto

    Citation: Journal of Systems Chemistry 2010 1:12

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  16. Content type: Perspectives

    The mathematical form of the energy-entropy relationship is that of the relationship between the difference and the ratio of any two 'entities' x and y creating a geometrical 3D projection x = y·z, i.e., a surfac...

    Authors: Peter Strazewski

    Citation: Journal of Systems Chemistry 2010 1:11

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  17. Content type: Research article

    The metabolic architectures of extant organisms share many key pathways such as the citric acid cycle, glycolysis, or the biosynthesis of most amino acids. Several competing hypotheses for the evolutionary mec...

    Authors: Christoph Flamm, Alexander Ullrich, Heinz Ekker, Martin Mann, Daniel Högerl, Markus Rohrschneider, Sebastian Sauer, Gerik Scheuermann, Konstantin Klemm, Ivo L Hofacker and Peter F Stadler

    Citation: Journal of Systems Chemistry 2010 1:4

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  18. Content type: Research article

    When the free energy of similar but distinct molecule-sized objects is plotted against the temperature at which their energy and entropy contributions cancel, a highly significant linear dependence results fro...

    Authors: Petr Zimak, Silvia Terenzi and Peter Strazewski

    Citation: Journal of Systems Chemistry 2010 1:2

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  19. Content type: Research article

    The "RNA World" hypothesis suggests that an early form of life on Earth was based on nucleic acid strands able to store genetic information and catalyze a wide range of reactions including those which lead to ...

    Authors: Olga Taran, Oliver Thoennessen, Karin Achilles and Günter von Kiedrowski

    Citation: Journal of Systems Chemistry 2010 1:9

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  20. Content type: Perspectives

    Today most chemists think that the answer to how life on earth emerged is still unknown. They assume a gap between chemistry and biology that is still unbridged. For chemists, understanding the origin of life ...

    Authors: Hans Kuhn

    Citation: Journal of Systems Chemistry 2010 1:3

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  21. Content type: Review

    Recent reports about enantioselective organoautocatalytic systems, in which small organic molecules assist in their own formation and under conservation of their absolute configuration, are discussed. This pro...

    Authors: Svetlana B Tsogoeva

    Citation: Journal of Systems Chemistry 2010 1:8

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  22. Content type: Preliminary communication

    A self-replicating system based on a cycloaddition of a fulvene derivative and a maleinimide is investigated using a two-pronged approach combining NMR spectroscopy with computer simulations. In the course of ...

    Authors: Arne Dieckmann, Sabrina Beniken, Christian Lorenz, Nikos L Doltsinis and Günter von Kiedrowski

    Citation: Journal of Systems Chemistry 2010 1:10

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  23. Content type: Research article

    In earlier studies, we showed that certain low-molecular-weight carboxylic acids (profens, amino acids, hydroxy acids) can undergo spontaneous in vitro chiral conversion accompanied by condensation to from oligom...

    Authors: Mieczysław Sajewicz, Monika Gontarska, Dorota Kronenbach, Marcin Leda, Teresa Kowalska and Irving R Epstein

    Citation: Journal of Systems Chemistry 2010 1:7

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  24. Content type: Research article

    The origin of homochirality of organic compounds such as L-amino acids and D-sugars have intrigued many scientists, and several hypotheses regarding its homochirality have been proposed. According to the stati...

    Authors: Kenta Suzuki, Kunihiko Hatase, Daisuke Nishiyama, Tsuneomi Kawasaki and Kenso Soai

    Citation: Journal of Systems Chemistry 2010 1:5

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  25. Content type: Editorial

    It is our utmost pleasure to launch the Journal of Systems Chemistry. What systems chemistry exactly is will be known in a few years from now when one is able to sketch the scope and vision of the field also b...

    Authors: Günter von Kiedrowski, Sijbren Otto and Piet Herdewijn

    Citation: Journal of Systems Chemistry 2010 1:1

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